| 1. Identity statement | |
| Reference Type | Journal Article |
| Site | plutao.sid.inpe.br |
| Holder Code | isadg {BR SPINPE} ibi 8JMKD3MGPCW/3DT298S |
| Identifier | 8JMKD3MGP3W/474P4LL |
| Repository | sid.inpe.br/plutao/2022/06.15.13.15 (restricted access) |
| Last Update | 2022:06.20.17.35.03 (UTC) lattes |
| Metadata Repository | sid.inpe.br/plutao/2022/06.15.13.15.20 |
| Metadata Last Update | 2023:01.03.16.52.56 (UTC) administrator |
| ISSN | 2574-1241 |
| Label | lattes: 3455204481678421 7 WacheskHuCoTaVaCoTr:2022:SyCVDi |
| Citation Key | WacheskHuCoTaVaCoTr:2022:SyCVDi |
| Title | Synthesis of CVD Diamond Nanoparticles and Cytotoxicity Evaluation in Murine Metastatic Melanoma Cells  |
| Year | 2022 |
| Access Date | 2024, May 19 |
| Type of Work | journal article |
| Secondary Type | PRE PI |
| Number of Files | 1 |
| Size | 2772 KiB |
| 2. Context | |
| Author | 1 Wachesk, Cristiane da Costa 2 Hurtado, Carolina R. 3 Correia, Rebeca Falcão Borja de Oliveira 4 Tada, Dayane Batista 5 Vasconcelos, Getúlio de 6 Corat, Evaldo José 7 Trava-Airoldi, Vladimir Jesus |
| Resume Identifier | 1 2 3 4 5 6 8JMKD3MGP5W/3C9JH33 |
| Group | 1 2 3 4 5 6 COPDT-CGIP-INPE-MCTI-GOV-BR 7 COPDT-CGIP-INPE-MCTI-GOV-BR |
| Affiliation | 1 Universidade Federal de São Paulo (UNIFESP) 2 Universidade Federal de São Paulo (UNIFESP) 3 Universidade Federal de São Paulo (UNIFESP) 4 Universidade Federal de São Paulo (UNIFESP) 5 Instituto de Estudos Avançados (IEAv) 6 Instituto Nacional de Pesquisas Espaciais (INPE) 7 Instituto Nacional de Pesquisas Espaciais (INPE) |
| Author e-Mail Address | 1 2 3 4 5 6 evaldo.corat@inpe.br 7 vladimirjta@gmail.com |
| Journal | Biomedical: Journal of Scientific and Technical Research |
| Volume | 41 |
| Number | 3 |
| Pages | 32695 |
| History (UTC) | 2022-06-20 17:35:05 :: lattes -> administrator :: 2022 2023-01-03 16:52:56 :: administrator -> simone :: 2022 |
| 3. Content and structure | |
| Is the master or a copy? | is the master |
| Content Stage | completed |
| Transferable | 1 |
| Content Type | External Contribution |
| Version Type | publisher |
| Keywords | Nano partículas Diamante-CVD Melanoma Cells citotoxicidade Murine |
| Abstract | Diamond nanoparticles (DNPs) have demonstrated in vitro and in vivo biomedical applicability due to their low toxicity and biocompatibility. Recent studies have focused on the potential use of DNPs as suitable vehicles to improve drug delivery in cancer treatment. The advantages of DNPs lie in their high stability and small size compared to other carbon-based nanomaterials. In this work, CVD-diamond nanoparticles (CVDDNPs) were synthesized and evaluated for their application as a new drug delivery platform for metastatic melanoma therapy. A new synthesis technique developed DNPs from CVD diamond thin film. This type of diamond has the same physical and chemical properties as a natural diamond: extreme hardness, excellent thermal conductivity, low coefficient of friction, biocompatibility, and is chemically inert at temperatures below 800 °C. The main objective of this study was to produce CVD-DNPs by laser ablation and evaluate their cytotoxicity. A pulsed, ytterbium-doped fiber (Yb) was used to form DNPs in pure aqueous medium (Milli-Q). The final suspension was obtained at high concentration of the CVD-DNPs and was used to evaluate the cytotoxicity in murine metastatic melanoma B16-F10 cells by using colorimetric assays. The characterization by FT-IR, X-Ray, DLS, RAMAN, SEM, and TEM demonstrated the successful synthesis of CVD-DNPs with a hydrodynamic diameter of 57 and 54 nm. In vitro studies performed for 24 h and 48 h resulted in 7080% viability of cells incubated with CVD-DNPs at 250 μg/mL, which demonstrated an insignificant cytotoxic effect. Thus, these results suggest the potential use of CVD-DNPs as a drug delivery platform for antitumoral therapy. |
| Area | FISMAT |
| Arrangement | urlib.net > BDMCI > Fonds > Produção a partir de 2021 > CGIP > Synthesis of CVD... |
| doc Directory Content | access |
| source Directory Content | there are no files |
| agreement Directory Content | there are no files |
| 4. Conditions of access and use | |
| Language | en |
| Target File | BJSTR.MS.ID.006604.pdf |
| User Group | lattes |
| Reader Group | administrator lattes |
| Visibility | shown |
| Read Permission | deny from all and allow from 150.163 |
| Update Permission | not transferred |
| 5. Allied materials | |
| Next Higher Units | 8JMKD3MGPCW/46KUES5 |
| Citing Item List | sid.inpe.br/bibdigital/2022/04.03.23.11 1 |
| Host Collection | dpi.inpe.br/plutao@80/2008/08.19.15.01 |
| 6. Notes | |
| Empty Fields | alternatejournal archivingpolicy archivist callnumber copyholder copyright creatorhistory descriptionlevel dissemination doi e-mailaddress format isbn lineage mark mirrorrepository month nextedition notes orcid parameterlist parentrepositories previousedition previouslowerunit progress project rightsholder schedulinginformation secondarydate secondarykey secondarymark session shorttitle sponsor subject tertiarymark tertiarytype url |
| 7. Description control | |
| e-Mail (login) | simone |
| update | |